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Insulin-like Growth Factor-1 (IGF-1) is a hormone produced primarily in the liver in response to growth hormone (GH) stimulation
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The RA, characterized by synovial inflammation, leads to cartilage and bone destruction, significantly impairing quality of life and increasing mortality risk by 1.5 - 2-fold compared to the general population (3)
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All mice utilized in the study were group housed, up to five per cage, and given nestlets (Ancare Corp, Bellmore, NY) to provide activity and stimulation